Searchable abstracts of presentations at key conferences in endocrinology

ea0081p428 | Pituitary and Neuroendocrinology | ECE2022

RNA profiling of human growth hormone-secreting and non-functioning pituitary adenomas reveals novel and differentially expressed immune related genes

Spiteri Emma Jayne , Formosa Robert , Paul Ebejer Jean , Paul Pace Nikolai , Gruppetta Mark , Saliba David , Vassallo Josanne

Pituitary neuroendocrine tumours (PitNETs) are broadly classified as non-functioning pituitary adenomas (NFPAs) and functional pituitary adenomas (FPAs) which include growth hormone secreting adenomas (GHPAs). Since the role of the immune system in PitNET pathogenesis is still poorly understood, we employed RNA-sequencing technology to unravel differentially expressed genes in GHPAs and NFPAs. Here we present an RNA-sequencing workflow of GHPAs (n=3) and NFPAs (n<...